CapsulesClinical Overview
Itraconazole is a synthetic triazole broad-spectrum antifungal on the WHO Model List of Essential Medicines. It inhibits fungal cytochrome P450 14-alpha-demethylase (CYP51), blocking conversion of lanosterol to ergosterol and destabilizing the fungal cell membrane. Features high lipophilicity and keratin affinity, persisting in nails for months after completion. Indicated for onychomycosis, dermatophytosis refractory to topical therapy, pityriasis versicolor, systemic aspergillosis, histoplasmosis, blastomycosis, and candidiasis.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Swallow capsules whole with a full glass of water immediately after a full meal or with an acidic beverage (e.g. cola), as gastric acidity and dietary fat are critical for absorption. Do not open or chew capsules. Do not take within 2 hours of antacids or H2 blockers/PPIs.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea, abdominal pain, diarrhea, headache, dizziness, dyspepsia, rash, transient transaminitis. Rare/Severe: Boxed warning: Congestive heart failure (negative inotropic effect); severe hepatotoxicity/liver failure, QT prolongation with torsades de pointes, and severe hypokalemia.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black box warning: Do not administer for onychomycosis in patients with evidence of ventricular dysfunction such as congestive heart failure. Potent inhibitor of CYP3A4; contraindicated with simvastatin, lovastatin, midazolam, cisapride, and quinidine. Monitor liver function tests in therapy exceeding 1 month.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered dermatologist or qualified medical practitioner before initiating, altering, or substituting any topical or systemic dermatological treatment.
Clotrimazole Cream 1%
Clotrimazole (1% w/w cream, lotion, or dusting powder) is a versatile broad-spectrum imidazole antifungal on the WHO Model List of Essential Medicines. It inhibits fungal cytochrome P450 14-alpha-demethylase, depleting ergosterol and increasing fungal cell permeability. Dusting powder formulation absorbs excess moisture in intertriginous skin folds, preventing fungal maceration. Indicated for tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis, and prevention of recurrence in sweaty body folds.
Ketoconazole Lotion 2%
Ketoconazole topical cream (2% w/v) is a broad-spectrum imidazole antifungal agent. It disrupts fungal cell membranes by inhibiting 14-alpha-demethylase, eradicating dermatophytes, Candida species, and Malassezia yeasts. Indicated for tinea corporis, tinea cruris, tinea pedis, cutaneous candidiasis, and pityriasis versicolor.
Itraconazole Capsules 100 mg
Itraconazole is a synthetic triazole broad-spectrum antifungal on the WHO Model List of Essential Medicines. It inhibits fungal cytochrome P450 14-alpha-demethylase (CYP51), blocking conversion of lanosterol to ergosterol and destabilizing the fungal cell membrane. Features high lipophilicity and keratin affinity, persisting in nails for months after completion. Indicated for onychomycosis, dermatophytosis refractory to topical therapy, pityriasis versicolor, systemic aspergillosis, histoplasmosis, blastomycosis, and candidiasis.
Terbinafine Tablets 250mg
Terbinafine Hydrochloride is an oral synthetic allylamine broad-spectrum fungicidal agent on the WHO Model List of Essential Medicines. It non-competitively inhibits squalene epoxidase, an essential early enzyme in fungal ergosterol biosynthesis. This induces intracellular accumulation of toxic squalene and depletion of ergosterol, causing fungal cell membrane lysis. Highly lipophilic and keratophilic, accumulating in stratum corneum, hair follicles, and nails. Indicated for tinea unguium (onychomycosis of toenails/fingernails), extensive tinea corporis/cruris, and severe tinea pedis.