TabletsClinical Overview
Imeglimin Hydrochloride (500 mg, 1000 mg) is a first-in-class oral tetrahydrotriazine derivative "glimin" antidiabetic agent. It targets mitochondrial bioenergetics across multiple organs: in the pancreas, it restores glucose-stimulated insulin secretion by increasing mitochondrial ATP and closing K_ATP channels while protecting beta cells against apoptosis; in the liver, it inhibits complex I of the respiratory chain, suppressing excessive gluconeogenesis; and in skeletal muscle, it enhances complex III activity, improving mitochondrial fatty acid oxidation and glucose uptake. Indicated for the treatment of type 2 diabetes mellitus as monotherapy or adjunct to other antidiabetic agents.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally twice daily with breakfast and dinner with a glass of water. Swallow whole.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea, diarrhea, abdominal pain, vomiting, dyspepsia. Rare/Severe: Hypoglycemia (when combined with insulin or sulfonylureas).
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Caution in moderate-to-severe renal impairment. Discontinue if severe gastrointestinal intolerance persists.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered endocrinologist, diabetologist, or qualified physician before initiating, adjusting dosages of, or substituting any antidiabetic or hormonal medication.