CreamMRP Under Process
Official PMBI MRP is being updated for catalog code 2563.
Locate Jan Aushadhi KendraClinical Overview
Hydroquinone, Tretinoin, and Fluocinolone Acetonide is the gold-standard Triple Combination Cream (Kligman's formula) for refractory melasma. Hydroquinone (2-4%) competitively inhibits tyrosinase, blocking melanin pigment synthesis; Tretinoin (0.05%) accelerates epidermal turnover and keratinocyte shedding, facilitating hydroquinone penetration and dispersing melanin; and Fluocinolone Acetonide (0.01%), a mild-to-moderate topical corticosteroid, suppresses melanocyte inflammation and counteracts the irritant dermatitis of hydroquinone and tretinoin. Indicated for the short-term moderate-to-severe melasma of the face.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Apply a tiny pea-sized amount at bedtime to pigmented areas and about 1/2 inch of surrounding normal skin, at least 30 minutes before sleep. Gently rub in. Wash face in the morning and apply broad-spectrum SPF 50+ sunscreen immediately. Maximum continuous duration: 8 to 12 weeks.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Erythema, peeling, burning, stinging, skin dryness, pruritus. Rare/Severe: Exogenous ochronosis (permanent blue-black skin darkening with prolonged overuse of hydroquinone), cutaneous atrophy (skin thinning), telangiectasia, and perioral dermatitis.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Strict limitation: Do not use continuously for more than 12 weeks to prevent permanent exogenous ochronosis and steroid-induced skin thinning. Strictly contraindicated during pregnancy and breastfeeding (teratogenic tretinoin risk). Daily strict photoprotection (broad-spectrum SPF 50+ and wide-brimmed hat) is mandatory.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered dermatologist or qualified medical practitioner before initiating, altering, or substituting any topical or systemic dermatological treatment.
Adapalene Gel 0.1%
Adapalene (0.1% w/w gel) is a third-generation synthetic retinoid on the WHO Model List of Essential Medicines. It selectively modulates cellular differentiation and keratinization by binding to retinoic acid receptors beta and gamma, inhibiting microcomedone formation and down-regulating inflammatory lipoxygenase pathways. Exhibits greater chemical stability and lower cutaneous irritation than tretinoin. Indicated for the topical treatment of acne vulgaris.
Hydroquinone 2%, Mometasone 0.1% and Tretinoin 0.025% Cream
Hydroquinone, Tretinoin, and Fluocinolone Acetonide is the gold-standard Triple Combination Cream (Kligman's formula) for refractory melasma. Hydroquinone (2-4%) competitively inhibits tyrosinase, blocking melanin pigment synthesis; Tretinoin (0.05%) accelerates epidermal turnover and keratinocyte shedding, facilitating hydroquinone penetration and dispersing melanin; and Fluocinolone Acetonide (0.01%), a mild-to-moderate topical corticosteroid, suppresses melanocyte inflammation and counteracts the irritant dermatitis of hydroquinone and tretinoin. Indicated for the short-term moderate-to-severe melasma of the face.
Betamethasone Dipropionate 0.05% and Salicylic Acid 3% Ointment
Betamethasone Valerate / Dipropionate is a potent topical corticosteroid on the WHO Model List of Essential Medicines. It suppresses cutaneous inflammatory edema, erythema, and pruritus in eczema, psoriasis, and severe contact dermatitis. Often formulated in combination with Fusidic Acid, Gentamicin, or Miconazole to treat secondarily infected dermatoses.
Miconazole 2% and Fluocinolone Acetonide 0.01% Ointment
Fluocinolone Acetonide / Fluocinonide is an intermediate-to-high potency fluorinated topical corticosteroid. It suppresses cutaneous inflammation and capillary permeability. Indicated for atopic dermatitis, severe contact dermatitis, and lichenified eczema.