InjectionClinical Overview
Ferric Carboxymaltose Injection (50mg/ml elemental iron, 500mg/10ml vial) is a non-dextran, macromolecular colloidal iron complex on the WHO Model List of Essential Medicines. Its polynuclear iron(III)-hydroxide core is stabilized by a carbohydrate carboxymaltose matrix that tightly binds iron, preventing free labile toxic iron release while delivering rapid targeted iron uptake to the reticuloendothelial system for ferritin storage and hemoglobin synthesis. Allows rapid administration of high single doses (up to 1000 mg elemental iron in 15 minutes). Indicated for treatment of iron deficiency anemia when oral iron preparations are ineffective or cannot be tolerated, and in non-dialysis chronic kidney disease, heart failure (NYHA class II-III with iron deficiency), and severe postpartum/menorrhagic anemia.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administer intravenously only by slow undiluted IV push (up to 500 mg over 2 to 5 minutes) or as an IV infusion (up to 1000 mg diluted strictly in sterile 0.9% NaCl over at least 15 minutes). Maximum single dose: 1000 mg iron (or 15 mg/kg) per week. Observe patient for hypersensitivity for at least 30 minutes following administration. Never administer IM.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Transient hypophosphatemia (serum phosphate drop in up to 30-50%), headache, dizziness, nausea, injection site discoloration/extravasation staining, flushing, hypertension. Rare/Severe: Severe anaphylactoid reactions, severe persistent hypophosphatemic osteomalacia, and hypotension.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Extravasation causes permanent long-lasting brown skin discoloration; ensure patent IV access before infusion. Monitor for signs of severe hypersensitivity; facilities for resuscitation must be available. Monitor serum phosphate levels in patients requiring multiple repeated courses.
Medical Disclaimer: Statutory Nutritional & Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice or clinical dietetic guidance. Dietary supplements, micronutrients, parenteral electrolytes, and specialized clinical nutrition should be used under the supervision of a registered medical practitioner or clinical nutritionist.