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Official PMBI MRP is being updated for catalog code 2384.
Locate Jan Aushadhi KendraClinical Overview
Amorolfine Hydrochloride (0.25% cream or 5% nail lacquer) is a morpholine-class broad-spectrum fungicidal agent. It inhibits two distinct sequential enzymes in fungal sterol biosynthesis: delta-14-reductase and delta-7,8-isomerase, depleting ergosterol and causing accumulation of atypical ignosterol in fungal membranes. Nail lacquer forms a non-water-soluble lacquer film that penetrates the nail plate to the nail bed, maintaining high antifungal concentrations for over a week. Indicated for distal and lateral subungual onychomycosis (without matrix involvement) and superficial dermatomycoses.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
File down the affected nail surface with an emery board before the first application. Clean the nail surface with the cleansing swab provided. Apply lacquer evenly over the entire nail plate once or twice weekly. Allow to dry for 3 minutes. Repeat weekly for 6 months (fingernails) to 9-12 months (toenails).
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Localized nail discoloration, brittle nails, burning sensation around nail fold, mild erythema. Rare/Severe: Periungual contact dermatitis.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Do not use cosmetic nail varnishes or artificial nails on treated nails during therapy. Avoid lacquer contact with eyes, ears, and mucous membranes.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered dermatologist or qualified medical practitioner before initiating, altering, or substituting any topical or systemic dermatological treatment.
Clotrimazole Cream 1%
Clotrimazole (1% w/w cream, lotion, or dusting powder) is a versatile broad-spectrum imidazole antifungal on the WHO Model List of Essential Medicines. It inhibits fungal cytochrome P450 14-alpha-demethylase, depleting ergosterol and increasing fungal cell permeability. Dusting powder formulation absorbs excess moisture in intertriginous skin folds, preventing fungal maceration. Indicated for tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis, and prevention of recurrence in sweaty body folds.
Ketoconazole Lotion 2%
Ketoconazole topical cream (2% w/v) is a broad-spectrum imidazole antifungal agent. It disrupts fungal cell membranes by inhibiting 14-alpha-demethylase, eradicating dermatophytes, Candida species, and Malassezia yeasts. Indicated for tinea corporis, tinea cruris, tinea pedis, cutaneous candidiasis, and pityriasis versicolor.
Itraconazole Capsules 100 mg
Itraconazole is a synthetic triazole broad-spectrum antifungal on the WHO Model List of Essential Medicines. It inhibits fungal cytochrome P450 14-alpha-demethylase (CYP51), blocking conversion of lanosterol to ergosterol and destabilizing the fungal cell membrane. Features high lipophilicity and keratin affinity, persisting in nails for months after completion. Indicated for onychomycosis, dermatophytosis refractory to topical therapy, pityriasis versicolor, systemic aspergillosis, histoplasmosis, blastomycosis, and candidiasis.
Terbinafine Tablets 250mg
Terbinafine Hydrochloride is an oral synthetic allylamine broad-spectrum fungicidal agent on the WHO Model List of Essential Medicines. It non-competitively inhibits squalene epoxidase, an essential early enzyme in fungal ergosterol biosynthesis. This induces intracellular accumulation of toxic squalene and depletion of ergosterol, causing fungal cell membrane lysis. Highly lipophilic and keratophilic, accumulating in stratum corneum, hair follicles, and nails. Indicated for tinea unguium (onychomycosis of toenails/fingernails), extensive tinea corporis/cruris, and severe tinea pedis.