GelClinical Overview
Nintedanib Soft Gelatin Capsules (100mg, 150mg) is an oral triple angiokinase inhibitor that targets receptor tyrosine kinases for vascular endothelial growth factor (VEGFR-1/2/3), fibroblast growth factor (FGFR-1/2/3), and platelet-derived growth factor (PDGFR-alpha/beta). In pulmonary fibrosis, it inhibits proliferation, migration, and transformation of lung fibroblasts into myofibroblasts, slowing the rate of pulmonary function decline (FVC loss). Indicated for Idiopathic Pulmonary Fibrosis (IPF), chronic fibrosing interstitial lung diseases with a progressive phenotype, systemic sclerosis-associated ILD, and in combination with docetaxel for advanced NSCLC of adenocarcinoma histology.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 150 mg twice daily (morning and evening), approximately 12 hours apart strictly WITH FOOD with a full glass of water. Swallow capsules whole; do NOT chew or crush to avoid bitter taste and esophageal irritation.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Diarrhea (occurs in >60% of patients), nausea, abdominal pain, vomiting, weight loss, elevated liver enzymes (ALT, AST, alkaline phosphatase). Rare/Severe: Drug-induced liver injury / jaundice, arterial thromboembolism, gastrointestinal perforation, and severe bleeding.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warning: Embryofetal toxicity (Category X); strict contraception required. Monitor liver function tests (ALT, AST, bilirubin) prior to initiation, monthly for the first 3 months, and periodically thereafter. Manage diarrhea immediately with hydration and loperamide.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, oncological diagnosis, or chemotherapy protocol guidance. Cancer therapies require specialized administration under the direct supervision of a registered medical oncologist in an accredited healthcare facility.