GelClinical Overview
Adapalene and Benzoyl Peroxide is a synergistic dual-mechanism topical anti-acne formulation. Adapalene (0.1%), a third-generation synthetic naphthoic acid retinoid, binds selectively to nuclear retinoic acid receptors (RAR-beta and RAR-gamma) to normalize follicular epithelial desquamation and resolve microcomedones while exerting potent anti-inflammatory effects. Benzoyl Peroxide (2.5%) releases bactericidal reactive oxygen species that rapidly kill Cutibacterium acnes without inducing bacterial resistance, and provides mild keratolysis. Indicated for the topical treatment of acne vulgaris with both inflammatory papules/pustules and non-inflammatory comedones.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Wash face gently with a mild cleanser and pat completely dry. Apply a thin pea-sized layer to the entire affected area of the face once daily in the evening before bedtime. Avoid eyes, lips, angles of the nose, and mucous membranes. Use a non-comedogenic moisturizer to manage initial dryness. Apply broad-spectrum sunscreen daily.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Erythema, scaling, dryness, stinging/burning sensation, localized skin irritation, photosensitivity. Rare/Severe: Severe contact dermatitis, blistering, and facial edema.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Benzoyl peroxide will bleach hair and dyed fabrics/towels; wash hands thoroughly after application. Avoid excessive sunlight, tanning beds, and UV exposure; use broad-spectrum SPF 30+ sunscreen daily. Do not apply to cuts, abrasions, or eczema.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered dermatologist or qualified medical practitioner before initiating, altering, or substituting any topical or systemic dermatological treatment.
Adapalene Gel 0.1%
Adapalene (0.1% w/w gel) is a third-generation synthetic retinoid on the WHO Model List of Essential Medicines. It selectively modulates cellular differentiation and keratinization by binding to retinoic acid receptors beta and gamma, inhibiting microcomedone formation and down-regulating inflammatory lipoxygenase pathways. Exhibits greater chemical stability and lower cutaneous irritation than tretinoin. Indicated for the topical treatment of acne vulgaris.
Hydroquinone 2%, Mometasone 0.1% and Tretinoin 0.025% Cream
Hydroquinone, Tretinoin, and Fluocinolone Acetonide is the gold-standard Triple Combination Cream (Kligman's formula) for refractory melasma. Hydroquinone (2-4%) competitively inhibits tyrosinase, blocking melanin pigment synthesis; Tretinoin (0.05%) accelerates epidermal turnover and keratinocyte shedding, facilitating hydroquinone penetration and dispersing melanin; and Fluocinolone Acetonide (0.01%), a mild-to-moderate topical corticosteroid, suppresses melanocyte inflammation and counteracts the irritant dermatitis of hydroquinone and tretinoin. Indicated for the short-term moderate-to-severe melasma of the face.
Betamethasone Dipropionate 0.05% and Salicylic Acid 3% Ointment
Betamethasone Valerate / Dipropionate is a potent topical corticosteroid on the WHO Model List of Essential Medicines. It suppresses cutaneous inflammatory edema, erythema, and pruritus in eczema, psoriasis, and severe contact dermatitis. Often formulated in combination with Fusidic Acid, Gentamicin, or Miconazole to treat secondarily infected dermatoses.
Adapalene 0.1% and Clindamycin Phosphate 1% Gel
Adapalene (0.1% w/w gel) is a third-generation synthetic retinoid on the WHO Model List of Essential Medicines. It selectively modulates cellular differentiation and keratinization by binding to retinoic acid receptors beta and gamma, inhibiting microcomedone formation and down-regulating inflammatory lipoxygenase pathways. Exhibits greater chemical stability and lower cutaneous irritation than tretinoin. Indicated for the topical treatment of acne vulgaris.