Clinical Overview
Thiamine Hydrochloride Injection (100mg/ml) is a sterile parenteral formulation of Vitamin B1 on the WHO Model List of Essential Medicines. Coenzyme for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase in carbohydrate metabolism. Indicated for life-saving emergency treatment of acute Wernicke-Korsakoff encephalopathy, severe beriberi (wet and dry), and alcohol withdrawal syndrome.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administer intravenously or intramuscularly: 100 mg to 500 mg IV infusion over 30 minutes three times daily for 3 to 5 days, followed by oral thiamine. CRITICAL RULE: In malnourished or alcoholic patients, ALWAYS administer IV thiamine BEFORE or CONCURRENTLY WITH IV glucose infusions (giving IV glucose before thiamine precipitates acute fatal Wernicke's encephalopathy).
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Local injection pain, warmth. Rare/Severe: Anaphylactoid shock with rapid IV push, and angioedema.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
ALWAYS give thiamine BEFORE intravenous glucose in alcoholic/malnourished patients to prevent precipitating fatal Wernicke encephalopathy. Inject slowly.
Medical Disclaimer: Statutory Nutritional & Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice or clinical dietetic guidance. Dietary supplements, micronutrients, parenteral electrolytes, and specialized clinical nutrition should be used under the supervision of a registered medical practitioner or clinical nutritionist.