SolutionClinical Overview
Sodium Valproate / Divalproex Sodium is a broad-spectrum antiepileptic and mood stabilizer on the WHO Model List of Essential Medicines. It increases brain gamma-aminobutyric acid (GABA) levels by inhibiting GABA transaminase and succinic semialdehyde dehydrogenase, while blocking voltage-gated T-type calcium channels and sustained repetitive firing of voltage-sensitive sodium channels. Indicated for generalized and focal epilepsy (absence, myoclonic, tonic-clonic seizures), acute manic episodes in bipolar disorder, and migraine prophylaxis.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Shake syrup well before measuring. Administer with calibrated spoon/syringe. Take with or after meals to prevent gastric irritation. Do not give with carbonated drinks which can cause mouth irritation.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea, dyspepsia, tremor, weight gain, alopecia (hair thinning), somnolence, thrombocytopenia. Rare/Severe: Boxed warnings: Fatal hepatotoxicity (highest in children < 2 years), life-threatening acute pancreatitis, severe teratogenicity (neural tube defects, cognitive impairment), and hyperammonemic encephalopathy.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warnings: (1) Fatal hepatic failure; (2) Life-threatening pancreatitis; (3) Major congenital malformations and neurodevelopmental disorders; strictly contraindicated in pregnancy for migraine prophylaxis and avoid in childbearing potential unless no alternative exists. Baseline and periodic LFTs, CBC, and serum valproate monitoring are mandatory.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Sodium Valproate Enteric Coated Tablets 200mg
Sodium Valproate / Divalproex Sodium is a broad-spectrum antiepileptic and mood stabilizer on the WHO Model List of Essential Medicines. It increases brain gamma-aminobutyric acid (GABA) levels by inhibiting GABA transaminase and succinic semialdehyde dehydrogenase, while blocking voltage-gated T-type calcium channels and sustained repetitive firing of voltage-sensitive sodium channels. Indicated for generalized and focal epilepsy (absence, myoclonic, tonic-clonic seizures), acute manic episodes in bipolar disorder, and migraine prophylaxis.
Sodium Valproate Gastro-Resistant Tablets 300mg
Sodium Valproate / Divalproex Sodium is a broad-spectrum antiepileptic and mood stabilizer on the WHO Model List of Essential Medicines. It increases brain gamma-aminobutyric acid (GABA) levels by inhibiting GABA transaminase and succinic semialdehyde dehydrogenase, while blocking voltage-gated T-type calcium channels and sustained repetitive firing of voltage-sensitive sodium channels. Indicated for generalized and focal epilepsy (absence, myoclonic, tonic-clonic seizures), acute manic episodes in bipolar disorder, and migraine prophylaxis.
Divalproex Tablets 500 mg
Sodium Valproate / Divalproex Sodium is a broad-spectrum antiepileptic and mood stabilizer on the WHO Model List of Essential Medicines. It increases brain gamma-aminobutyric acid (GABA) levels by inhibiting GABA transaminase and succinic semialdehyde dehydrogenase, while blocking voltage-gated T-type calcium channels and sustained repetitive firing of voltage-sensitive sodium channels. Indicated for generalized and focal epilepsy (absence, myoclonic, tonic-clonic seizures), acute manic episodes in bipolar disorder, and migraine prophylaxis.
Sodium Valproate 200mg + Valproic acid 87mg Controlled Release Tablets
Sodium Valproate / Divalproex Sodium is a broad-spectrum antiepileptic and mood stabilizer on the WHO Model List of Essential Medicines. It increases brain gamma-aminobutyric acid (GABA) levels by inhibiting GABA transaminase and succinic semialdehyde dehydrogenase, while blocking voltage-gated T-type calcium channels and sustained repetitive firing of voltage-sensitive sodium channels. Indicated for generalized and focal epilepsy (absence, myoclonic, tonic-clonic seizures), acute manic episodes in bipolar disorder, and migraine prophylaxis.