GelClinical Overview
Clindamycin and Nicotinamide topical gel is a dual-action anti-acne formulation. Clindamycin Phosphate (1% w/w) inhibits bacterial protein synthesis by binding to 50S ribosomes, eradicating Cutibacterium acnes, while Nicotinamide (4% w/w, Vitamin B3) exerts potent anti-inflammatory action by suppressing IL-8 and leukotriene-mediated neutrophil chemotaxis, reducing sebum production, and stabilizing the epidermal permeability barrier. Indicated for inflammatory acne vulgaris with papules and pustules.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Cleanse affected skin gently and pat dry. Apply a thin film to the entire affected area twice daily (morning and evening). Gently massage until absorbed.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Mild localized burning, dry skin, peeling, erythema, pruritus. Rare/Severe: Pseudomembranous colitis (extremely rare with topical use, but possible via systemic absorption).
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
For external topical dermatological use only. Discontinue if severe watery diarrhea or abdominal cramps develop. Avoid contact with eyes.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered dermatologist or qualified medical practitioner before initiating, altering, or substituting any topical or systemic dermatological treatment.
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