TabletsClinical Overview
Risperidone and Trihexyphenidyl (Benzhexol) is a therapeutic combination designed to provide antipsychotic efficacy while preventing drug-induced movement disorders. Risperidone, a benzisoxazole atypical antipsychotic, blocks dopamine D2 and serotonin 5-HT2A receptors to control psychosis, while trihexyphenidyl, a centrally acting anticholinergic agent, blocks muscarinic M1 receptors to restore the dopamine-acetylcholine balance in the basal ganglia, preventing extrapyramidal symptoms (acute dystonia, parkinsonian rigidity, tremors, akathisia). Indicated for schizophrenia, schizoaffective disorder, and severe psychotic agitation complicated by high extrapyramidal risk.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with water, or place mouth-dissolving tablet on tongue to disperse before swallowing. May be taken with or without food. Administer once or twice daily as prescribed. Taper slowly when discontinuing.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Sedation, dry mouth, constipation, blurred vision, weight gain, dizziness, urinary hesitancy. Rare/Severe: Tardive dyskinesia, neuroleptic malignant syndrome, hyperprolactinemia, and paralytic ileus.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Boxed warning for increased mortality in elderly dementia-related psychosis. Contraindicated in narrow-angle glaucoma, myasthenia gravis, and obstructive uropathy. Monitor prolactin, metabolic panel, and involuntary movements.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
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Risperidone is a benzisoxazole second-generation atypical antipsychotic on the WHO Model List of Essential Medicines. It possesses high-affinity antagonism at serotonin 5-HT2A and dopamine D2 receptors, as well as alpha-1 and alpha-2 adrenergic and H1 receptors. Indicated for schizophrenia in adults and adolescents, acute mania in bipolar I disorder, and irritability/severe aggression associated with autistic disorder in children.
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Risperidone is a benzisoxazole second-generation atypical antipsychotic on the WHO Model List of Essential Medicines. It possesses high-affinity antagonism at serotonin 5-HT2A and dopamine D2 receptors, as well as alpha-1 and alpha-2 adrenergic and H1 receptors. Indicated for schizophrenia in adults and adolescents, acute mania in bipolar I disorder, and irritability/severe aggression associated with autistic disorder in children.
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Risperidone is a benzisoxazole second-generation atypical antipsychotic on the WHO Model List of Essential Medicines. It possesses high-affinity antagonism at serotonin 5-HT2A and dopamine D2 receptors, as well as alpha-1 and alpha-2 adrenergic and H1 receptors. Indicated for schizophrenia in adults and adolescents, acute mania in bipolar I disorder, and irritability/severe aggression associated with autistic disorder in children.