TabletsClinical Overview
Phenobarbitone (Phenobarbital) is a long-acting barbiturate anticonvulsant on the WHO Model List of Essential Medicines. It binds allosterically to GABAA receptors, prolonging the open duration of neuronal chloride ion channels, enhancing GABA-mediated inhibition, and suppressing glutamate-mediated excitation. Indicated for generalized tonic-clonic seizures, focal seizures, and neonatal seizures.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with a full glass of water, usually as a single dose at bedtime, with or without food. Taper very slowly over several weeks when discontinuing to prevent life-threatening withdrawal seizures and status epilepticus.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Drowsiness, sedation, ataxia, cognitive impairment, behavioral hyperactivity in children, depression. Rare/Severe: Physical dependence and severe withdrawal syndrome, respiratory depression, megaloblastic anemia, Stevens-Johnson syndrome, and osteomalacia.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
High risk of dependence and severe withdrawal seizures; never stop abruptly. Potent inducer of hepatic microsomal enzymes; markedly accelerates clearance of oral contraceptives, anticoagulants, and steroids. Contraindicated in acute intermittent porphyria and severe respiratory depression.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Phenobarbitone Tablets 60 mg
Phenobarbitone (Phenobarbital) is a long-acting barbiturate anticonvulsant on the WHO Model List of Essential Medicines. It binds allosterically to GABAA receptors, prolonging the open duration of neuronal chloride ion channels, enhancing GABA-mediated inhibition, and suppressing glutamate-mediated excitation. Indicated for generalized tonic-clonic seizures, focal seizures, and neonatal seizures.
Phenobarbitone 200mg/1ml Injection
Phenobarbitone (Phenobarbital) is a long-acting barbiturate anticonvulsant on the WHO Model List of Essential Medicines. It binds allosterically to GABAA receptors, prolonging the open duration of neuronal chloride ion channels, enhancing GABA-mediated inhibition, and suppressing glutamate-mediated excitation. Indicated for generalized tonic-clonic seizures, focal seizures, and neonatal seizures.
Phenobarbitone Sodium 20mg per 5ml Syrup
Phenobarbitone (Phenobarbital) is a long-acting barbiturate anticonvulsant on the WHO Model List of Essential Medicines. It binds allosterically to GABAA receptors, prolonging the open duration of neuronal chloride ion channels, enhancing GABA-mediated inhibition, and suppressing glutamate-mediated excitation. Indicated for generalized tonic-clonic seizures, focal seizures, and neonatal seizures.