Temozolomide
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Oncology & Critical Care treatment.
🧴 Clinical Application
Take orally once daily on an empty stomach (at least 1 hour before or 2 hours after meals) at bedtime with a full glass of water. Swallow capsules whole; do NOT open, chew, or dissolve. During concomitant radiotherapy, take 75 mg/m² daily for 42 consecutive days with mandatory Pneumocystis jirovecii pneumonia (PCP) prophylaxis (e.g., co-trimoxazole).
⚠️ Side Effects
Common: Nausea, vomiting (routine prophylactic antiemetics advised), fatigue, headache, constipation, dose-limiting myelosuppression (thrombocytopenia, neutropenia). Rare/Severe: Prolonged pancytopenia, aplastic anemia, opportunistic infections (PCP pneumonia), and hepatic injury.
🛡️ Safety Warnings
Black Box Warning: Myelosuppression; monitor absolute neutrophil count (ANC) and platelets prior to each cycle. Mandatory PCP prophylaxis during concomitant radiotherapy phase due to severe lymphopenia. Patients with unmethylated MGMT gene promoters demonstrate lower clinical sensitivity. Teratogenic (Category D).
Jan Aushadhi Products containing Temozolomide
Found 3 generic formulation(s) containing this active ingredient.
Temozolomide Capsules 100mg
Temozolomide Capsules (20mg, 100mg, 250mg) is an oral imidazotetrazine alkylating prodrug on the WHO Model List of Essential Medicines. Unlike dacarbazine, it does not require hepatic enzymatic activation; at physiological systemic pH (7.4), it undergoes spontaneous non-enzymatic conversion to active MTIC, which methylates DNA at the O-6 and N-7 positions of guanine. O-6 methylguanine mispairs with thymine during replication, triggering repetitive futile mismatch repair cycles that culminate in lethal double-strand DNA breaks. Excellent blood-brain barrier penetration. Indicated for newly diagnosed Glioblastoma Multiforme (concomitant with radiotherapy and adjuvant maintenance, the Stupp protocol) and refractory anaplastic astrocytoma.
Temozolomide Capsules 250 mg
Temozolomide Capsules (20mg, 100mg, 250mg) is an oral imidazotetrazine alkylating prodrug on the WHO Model List of Essential Medicines. Unlike dacarbazine, it does not require hepatic enzymatic activation; at physiological systemic pH (7.4), it undergoes spontaneous non-enzymatic conversion to active MTIC, which methylates DNA at the O-6 and N-7 positions of guanine. O-6 methylguanine mispairs with thymine during replication, triggering repetitive futile mismatch repair cycles that culminate in lethal double-strand DNA breaks. Excellent blood-brain barrier penetration. Indicated for newly diagnosed Glioblastoma Multiforme (concomitant with radiotherapy and adjuvant maintenance, the Stupp protocol) and refractory anaplastic astrocytoma.
Temozolomide Capsules 20mg
Temozolomide Capsules (20mg, 100mg, 250mg) is an oral imidazotetrazine alkylating prodrug on the WHO Model List of Essential Medicines. Unlike dacarbazine, it does not require hepatic enzymatic activation; at physiological systemic pH (7.4), it undergoes spontaneous non-enzymatic conversion to active MTIC, which methylates DNA at the O-6 and N-7 positions of guanine. O-6 methylguanine mispairs with thymine during replication, triggering repetitive futile mismatch repair cycles that culminate in lethal double-strand DNA breaks. Excellent blood-brain barrier penetration. Indicated for newly diagnosed Glioblastoma Multiforme (concomitant with radiotherapy and adjuvant maintenance, the Stupp protocol) and refractory anaplastic astrocytoma.
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Temozolomide.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Temozolomide Capsules 100mg | 5's in Bottle | ₹1371.56 | TEMOSIDE, TEMCAD, TEMOTEC, TEMOTERO | ₹2168.86 | 37% Save |
| Temozolomide Capsules 250 mg | 5's | ₹2517.19 | GLIOZ, TEMODAL, TEMOTEC, TEMOTERO, GLIOTEM | ₹12908.09 | 80% Save |
| Temozolomide Capsules 20mg | 5's in bottle | ₹314.06 | TEMOSIDE | ₹580.27 | 46% Save |
Frequently Asked Questions (FAQ)
Get answers to common queries about Temozolomide generics.