Propofol

Active pharmaceutical substance formulated in Jan Aushadhi generic products for CNS, Nerve & Mental Health treatment.

🧴 Clinical Application

Administered solely by trained anesthesiologists or intensive care specialists via slow intravenous injection or titrated continuous IV infusion using an automated infusion pump. Continuous cardiopulmonary monitoring is mandatory. Strictly maintain aseptic technique; single-use emulsion vials must be discarded within 12 hours of opening.

⚠️ Side Effects

Common: Marked injection site pain (minimized with IV lidocaine), hypotension, transient apnea, bradycardia, involuntary muscle movements. Rare/Severe: Propofol Infusion Syndrome (PRIS: metabolic acidosis, rhabdomyolysis, hyperkalemia, hepatomegaly, renal failure, cardiac arrest), profound cardiovascular collapse, and pancreatitis.

🛡️ Safety Warnings

Black box warning: Administer only by persons trained in general anesthesia not involved in the surgical/diagnostic procedure. Strict restriction on infusion rate and duration (< 4-5 mg/kg/hr for < 48 hours) to prevent fatal Propofol Infusion Syndrome. Contraindicated in egg or soy allergy.