Pirfenidone
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Respiratory & Allergy treatment.
🧴 Clinical Application
Take orally WITH FOOD (during or immediately after meals) with a full glass of water. Titrate upward over 3 weeks: Week 1: 200 mg three times daily (600 mg/day); Week 2: 400 mg three times daily (1200 mg/day); Week 3 and maintenance: 600-800 mg three times daily (up to 1800-2403 mg/day). Taking with food significantly reduces nausea and dizziness.
⚠️ Side Effects
Common: Photosensitivity rash (severe sunburn reaction upon sun exposure in >30%), nausea, diarrhea, dyspepsia, anorexia, fatigue, weight loss, dizziness, elevated transaminases. Rare/Severe: Drug-induced liver injury / jaundice, and severe angioedema.
🛡️ Safety Warnings
Black Box Warning: Photosensitivity and rash; patients MUST apply broad-spectrum sunscreen (SPF >= 50), wear sun-protective clothing, and strictly avoid direct sunlight or tanning beds. Black Box Warning: Hepatotoxicity; monitor liver function tests (ALT, AST, bilirubin) prior to initiation, monthly for the first 6 months, and every 3 months thereafter. Avoid cigarette smoking (smoking induces CYP1A2, reducing pirfenidone plasma levels by 50%).
Jan Aushadhi Products containing Pirfenidone
Found 2 generic formulation(s) containing this active ingredient.
Pirfenidone Tablets 200mg
Pirfenidone Tablets (200mg, 400mg) is an oral synthetic pyridone antifibrotic and anti-inflammatory agent on the WHO Model List framework. It suppresses the synthesis of transforming growth factor-beta (TGF-beta), basic fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF), inhibiting fibroblast proliferation and extracellular matrix (collagen) deposition in pulmonary parenchyma. It also scavenges reactive oxygen species and inhibits TNF-alpha and IL-1beta. Clinically proven to reduce the rate of forced vital capacity (FVC) decline and disease progression. Indicated for the treatment of mild-to-moderate Idiopathic Pulmonary Fibrosis (IPF).
Pirfenidone Tablets 400mg
Pirfenidone Tablets (200mg, 400mg) is an oral synthetic pyridone antifibrotic and anti-inflammatory agent on the WHO Model List framework. It suppresses the synthesis of transforming growth factor-beta (TGF-beta), basic fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF), inhibiting fibroblast proliferation and extracellular matrix (collagen) deposition in pulmonary parenchyma. It also scavenges reactive oxygen species and inhibits TNF-alpha and IL-1beta. Clinically proven to reduce the rate of forced vital capacity (FVC) decline and disease progression. Indicated for the treatment of mild-to-moderate Idiopathic Pulmonary Fibrosis (IPF).
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Pirfenidone.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Pirfenidone Tablets 200mg | 10's | Under Process | N/A | N/A | N/A |
| Pirfenidone Tablets 400mg | 10's | ₹159.38 | N/A | N/A | N/A |
Frequently Asked Questions (FAQ)
Get answers to common queries about Pirfenidone generics.