Pemetrexed
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Oncology & Critical Care treatment.
🧴 Clinical Application
Administer intravenously only over 10 minutes diluted in 0.9% NaCl. MANDATORY PREMEDICATIONS: 1) Folic acid (350-1000 mcg orally daily) starting 1 week prior to the first dose and continuing for 21 days after the last dose; 2) Vitamin B12 (1000 mcg IM) starting 1 week prior and repeated every 9 weeks; 3) Dexamethasone (4 mg orally twice daily) for 3 days starting the day before pemetrexed to prevent severe cutaneous reactions.
⚠️ Side Effects
Common: Myelosuppression (neutropenia, anemia, thrombocytopenia), fatigue, nausea, anorexia, rash, pharyngitis, diarrhea. Rare/Severe: Fatal sepsis, severe renal failure, and radiation recall reaction.
🛡️ Safety Warnings
Mandatory folic acid and vitamin B12 supplementation is vital; failure to supplement leads to life-threatening myelosuppression and gastrointestinal toxicities. Ineffective in squamous cell lung cancer (use only in non-squamous NSCLC). Avoid NSAIDs in patients with mild-to-moderate renal impairment (CrCl 45-79 mL/min) around dosing.
Jan Aushadhi Products containing Pemetrexed
Found 2 generic formulation(s) containing this active ingredient.
Pemetrexed Injection 100 mg
Pemetrexed Injection (100mg, 500mg) is a pyrrolopyrimidine-based multi-targeted antifolate antineoplastic on the WHO Model List of Essential Medicines. It simultaneously inhibits three key enzymes required for purine and pyrimidine biosynthesis: thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). Indicated in combination with cisplatin (and as maintenance monotherapy) for locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma.
Pemetrexed Injection 500 mg
Pemetrexed Injection (100mg, 500mg) is a pyrrolopyrimidine-based multi-targeted antifolate antineoplastic on the WHO Model List of Essential Medicines. It simultaneously inhibits three key enzymes required for purine and pyrimidine biosynthesis: thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). Indicated in combination with cisplatin (and as maintenance monotherapy) for locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma.
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Pemetrexed.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Pemetrexed Injection 100 mg | VIAL | ₹759.38 | NATCO PHARMA LTD, SUN PHARMA, PAMIFECT | ₹2790.03 | 73% Save |
| Pemetrexed Injection 500 mg | VIAL | ₹2165.63 | VRTU, SUN PHARMA, PAMIFECT | ₹5146.43 | 58% Save |
Frequently Asked Questions (FAQ)
Get answers to common queries about Pemetrexed generics.