Paclitaxel

Active pharmaceutical substance formulated in Jan Aushadhi generic products for Oncology & Critical Care treatment.

🧴 Clinical Application

Administer intravenously only over 3 hours diluted in non-PVC containers and infused through an in-line 0.22-micron filter. MANDATORY PREMEDICATIONS to prevent lethal hypersensitivity to the polyoxyethylated castor oil (Cremophor EL) vehicle: 1) Dexamethasone 20 mg orally at 12 and 6 hours prior; 2) Diphenhydramine 50 mg IV 30-60 min prior; 3) Ranitidine 50 mg IV 30-60 min prior.

⚠️ Side Effects

Common: Complete alopecia, sensory peripheral neuropathy (glove-and-stocking numbness and paresthesias), dose-limiting neutropenia, myalgias, arthralgias. Rare/Severe: Fatal anaphylactic hypersensitivity reactions (dyspnea, flushing, chest pain, hypotension), cardiac conduction disturbances (bradycardia, heart block), and severe extravasation necrosis.

🛡️ Safety Warnings

Black Box Warning: Severe, potentially fatal hypersensitivity reactions; mandatory 3-drug premedication is strictly required. Black Box Warning: Severe neutropenia; monitor ANC (>1,500 cells/mm³ required). Must be infused using non-PVC IV tubing and containers to avoid DEHP plasticizer leaching.