Nitrofurantoin
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Kidney & Urinary Care treatment.
🧴 Clinical Application
Acute cystitis: Take 100 mg orally twice daily (sustained-release) or 50-100 mg four times daily with food or milk for 5 to 7 days. Swallow whole; do NOT crush. Taking with food enhances bioavailability by over 40% and reduces nausea. Long-term prophylaxis: 50 mg to 100 mg once daily at bedtime.
⚠️ Side Effects
Common: Nausea, anorexia, headache, flatulence, harmless dark yellow or brown discoloration of urine. Rare/Severe: Acute/chronic pulmonary toxicity (interstitial pneumonitis, pulmonary fibrosis), peripheral neuropathy, drug-induced hepatotoxicity, and hemolytic anemia in G6PD deficiency.
🛡️ Safety Warnings
Black Box Warning: Pulmonary toxicity with chronic use; monitor for cough, dyspnea, and chest pain. Strictly contraindicated in patients with significant renal impairment (eGFR < 30-45 mL/min) as inadequate urinary drug concentrations occur with increased systemic toxicities. Contraindicated in late pregnancy (38-42 weeks) due to neonatal hemolytic anemia risk. Ineffective for pyelonephritis or perinephric abscess.
Jan Aushadhi Products containing Nitrofurantoin
Found 3 generic formulation(s) containing this active ingredient.
Nitrofurantoin Tablets I.P 100mg
Nitrofurantoin Tablets / Sustained Release (50mg, 100mg) is a synthetic nitrofuran bactericidal antibiotic on the WHO Model List of Essential Medicines. Bacterial nitroreductases intracellularly reduce nitrofurantoin into highly reactive, short-lived electrophilic intermediates that indiscriminately attack bacterial ribosomal proteins, DNA, RNA, and metabolic enzymes. It concentrates specifically in renal tubular fluid and bladder urine (therapeutic urine concentrations >100 mcg/mL) with negligible systemic tissue levels, minimizing disruption to normal vaginal and bowel microflora and exhibiting minimal bacterial resistance after decades of use. Indicated for treatment and long-term prophylaxis of acute uncomplicated lower urinary tract infections (cystitis) caused by susceptible E. coli, Enterococcus faecalis, and Klebsiella species.
Nitrofurantoin 50mg Tablets
Nitrofurantoin Tablets / Sustained Release (50mg, 100mg) is a synthetic nitrofuran bactericidal antibiotic on the WHO Model List of Essential Medicines. Bacterial nitroreductases intracellularly reduce nitrofurantoin into highly reactive, short-lived electrophilic intermediates that indiscriminately attack bacterial ribosomal proteins, DNA, RNA, and metabolic enzymes. It concentrates specifically in renal tubular fluid and bladder urine (therapeutic urine concentrations >100 mcg/mL) with negligible systemic tissue levels, minimizing disruption to normal vaginal and bowel microflora and exhibiting minimal bacterial resistance after decades of use. Indicated for treatment and long-term prophylaxis of acute uncomplicated lower urinary tract infections (cystitis) caused by susceptible E. coli, Enterococcus faecalis, and Klebsiella species.
Nitrofurantoin Sustained Release Tablets 100mg
Nitrofurantoin Tablets / Sustained Release (50mg, 100mg) is a synthetic nitrofuran bactericidal antibiotic on the WHO Model List of Essential Medicines. Bacterial nitroreductases intracellularly reduce nitrofurantoin into highly reactive, short-lived electrophilic intermediates that indiscriminately attack bacterial ribosomal proteins, DNA, RNA, and metabolic enzymes. It concentrates specifically in renal tubular fluid and bladder urine (therapeutic urine concentrations >100 mcg/mL) with negligible systemic tissue levels, minimizing disruption to normal vaginal and bowel microflora and exhibiting minimal bacterial resistance after decades of use. Indicated for treatment and long-term prophylaxis of acute uncomplicated lower urinary tract infections (cystitis) caused by susceptible E. coli, Enterococcus faecalis, and Klebsiella species.
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Nitrofurantoin.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Nitrofurantoin Tablets I.P 100mg | 10's | ₹18.15 | NIFTAS, NIFURUTI, NITROFUR, NITROBEST, MARTIFUR | ₹89.45 | 80% Save |
| Nitrofurantoin 50mg Tablets | 10's | ₹13.50 | NIFTAS, MARTIFUR, NIftaS | ₹98.34 | 86% Save |
| Nitrofurantoin Sustained Release Tablets 100mg | 15's | ₹28.13 | NIFTAS, NIFURUTI, NITROFUR, NITROBEST, MARTIFUR | ₹134.18 | 79% Save |
Frequently Asked Questions (FAQ)
Get answers to common queries about Nitrofurantoin generics.