Myoinositol

Active pharmaceutical substance formulated in Jan Aushadhi generic products for Diabetes & Endocrine treatment.

🧴 Clinical Application

Take orally with or immediately after meals (breakfast and dinner) with a full glass of water. Starting with a low dose (500 mg once or twice daily) and titrating slowly over weeks substantially reduces gastrointestinal side effects. Swallow sustained-release/prolonged-release tablets whole; do not break, chew, or crush.

⚠️ Side Effects

Common: Diarrhea, nausea, vomiting, abdominal bloating, flatulence, anorexia, metallic taste, vitamin B12 deficiency with prolonged use. Rare/Severe: Boxed warning: Lactic acidosis (rare but life-threatening accumulation with 50% mortality); acute kidney injury, and severe megaloblastic anemia.

🛡️ Safety Warnings

Black box warning: Lactic acidosis; risk is heightened in renal impairment, sepsis, acute congestive heart failure, and heavy alcohol intake. Contraindicated if eGFR < 30 mL/min; dose should not exceed 1000 mg/day if eGFR is 30-44 mL/min. Must be withheld temporarily at the time of or prior to iodinated radiocontrast imaging procedures and for 48 hours post-procedure until renal function is re-evaluated. Periodic serum vitamin B12 monitoring is advised.