Megestrol

Active pharmaceutical substance formulated in Jan Aushadhi generic products for Oncology & Critical Care treatment.

🧴 Clinical Application

For cancer cachexia/anorexia: Take orally 400 mg to 800 mg daily in single or divided doses with water. For breast/endometrial cancer: 40 mg to 320 mg daily in divided doses. Shake oral suspensions thoroughly if used. Re-evaluate periodically.

⚠️ Side Effects

Common: Weight gain, increased appetite, peripheral edema, nausea, breakthrough vaginal bleeding, hot flushes, hypertension. Rare/Severe: Deep vein thrombosis / pulmonary embolism, secondary adrenal insufficiency (due to intrinsic glucocorticoid activity), and new-onset diabetes mellitus / hyperglycemia.

🛡️ Safety Warnings

Venous thromboembolic risk; use with caution in patients with a history of thrombophlebitis. Possesses substantial intrinsic glucocorticoid properties; long-term use suppresses pituitary-adrenal axis, requiring steroid tapering to avoid acute adrenal crisis during stress or discontinuation. Contraindicated in pregnancy.