Lopinavir

Active pharmaceutical substance formulated in Jan Aushadhi generic products for Antibiotics & Anti-Infectives treatment.

🧴 Clinical Application

Take orally once daily or twice daily at the exact same hour every single day. Strict lifelong adherence is paramount to prevent viral rebound and resistance mutation. Do not skip doses or alter timing without specialist guidance.

⚠️ Side Effects

Common: Headache, nausea, fatigue, insomnia, diarrhea, abnormal dreams (with efavirenz). Rare/Severe: Renal tubular dysfunction/Fanconi syndrome (tenofovir disoproxil), loss of bone mineral density, severe hypersensitivity (abacavir HLA-B*5701), lactic acidosis/severe hepatomegaly with steatosis, and immune reconstitution inflammatory syndrome (IRIS).

🛡️ Safety Warnings

Black box warnings: Exacerbation of Hepatitis B upon treatment discontinuation in co-infected patients. HLA-B*5701 genetic testing is mandatory prior to abacavir administration to prevent fatal hypersensitivity. Routine monitoring of renal function, bone density, viral load, and CD4 counts is essential.