Leflunomide
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Pain, Fever & Arthritis treatment.
🧴 Clinical Application
Take orally 10 mg to 20 mg once daily with water, with or without food. Swallow whole. Teriflunomide has an extremely long elimination half-life (~2 weeks) and undergoes enterohepatic recirculation. Cholestyramine washout protocol (8 g three times daily for 11 days) is required to rapidly eliminate the drug in toxicity or pregnancy planning.
⚠️ Side Effects
Common: Diarrhea, nausea, abdominal pain, alopecia (hair thinning), hypertension, headache, transaminase elevations. Rare/Severe: Severe hepatotoxicity / acute liver necrosis, severe teratogenicity / fetal death, interstitial lung disease, Stevens-Johnson syndrome, and pancytopenia.
🛡️ Safety Warnings
Black Box Warning: Severe hepatotoxicity; monitor ALT/AST monthly for the first 6 months and every 6-8 weeks thereafter; contraindicated in pre-existing liver disease. Black Box Warning: Severe embryofetal toxicity / teratogenicity (Category X); strict contraception required. If pregnancy is planned, accelerated drug elimination with cholestyramine is MANDATORY until plasma levels are <0.02 mg/L.
Jan Aushadhi Products containing Leflunomide
Found 2 generic formulation(s) containing this active ingredient.
Leflunomide Tablets 20mg
Leflunomide Tablets (10mg, 20mg) is an oral isoxazole-derivative disease-modifying antirheumatic drug (DMARD) on the WHO Model List of Essential Medicines. It is rapidly converted in the gut wall and liver to its active metabolite teriflunomide (A77 1726), which reversibly inhibits dihydroorotate dehydrogenase (DHODH), the key mitochondrial enzyme in de novo pyrimidine synthesis. Because activated, proliferating autoimmune T- and B-lymphocytes depend on de novo pyrimidine generation (unlike resting cells which use the salvage pathway), leflunomide selectively halts autoimmune lymphocyte proliferation and joint inflammation. Indicated for active Rheumatoid Arthritis and active Psoriatic Arthritis.
Leflunomide 10mg Tablets
Leflunomide Tablets (10mg, 20mg) is an oral isoxazole-derivative disease-modifying antirheumatic drug (DMARD) on the WHO Model List of Essential Medicines. It is rapidly converted in the gut wall and liver to its active metabolite teriflunomide (A77 1726), which reversibly inhibits dihydroorotate dehydrogenase (DHODH), the key mitochondrial enzyme in de novo pyrimidine synthesis. Because activated, proliferating autoimmune T- and B-lymphocytes depend on de novo pyrimidine generation (unlike resting cells which use the salvage pathway), leflunomide selectively halts autoimmune lymphocyte proliferation and joint inflammation. Indicated for active Rheumatoid Arthritis and active Psoriatic Arthritis.
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Leflunomide.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Leflunomide Tablets 20mg | 10's | ₹69.38 | LEFNO, LEFRA, LEFUMIDE, RUMALEF, DM LEF | ₹246.31 | 72% Save |
| Leflunomide 10mg Tablets | 10's | ₹32.81 | LEFNO, LEFRA, LEFUMIDE, LEFUHEAL | ₹135.45 | 76% Save |
Frequently Asked Questions (FAQ)
Get answers to common queries about Leflunomide generics.