Etoposide
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Oncology & Critical Care treatment.
🧴 Clinical Application
Injection: Administer by slow intravenous infusion diluted in 0.9% NaCl or 5% Dextrose over at least 30 to 60 minutes. NEVER administer as rapid IV push, which precipitates severe hypotension. Capsules: Take orally on an empty stomach with a full glass of water. Store capsules in a refrigerator (2-8°C).
⚠️ Side Effects
Common: Dose-limiting leukopenia/neutropenia (nadir at 7-14 days), alopecia (occurs in >60%), nausea, vomiting, anorexia, stomatitis. Rare/Severe: Severe hypotension with rapid IV infusion, secondary acute myeloid leukemia (t-AML with 11q23 translocations), and anaphylaxis.
🛡️ Safety Warnings
Black Box Warning: Dose-limiting bone marrow suppression; monitor complete blood counts before each cycle. Black Box Warning: Infuse IV slowly over >30-60 minutes to prevent acute severe hypotension. Secondary leukemia risk (treatment-related AML).
Jan Aushadhi Products containing Etoposide
Found 2 generic formulation(s) containing this active ingredient.
Etoposide Injection 100 mg per 5 ml
Etoposide Injection (100mg/5ml) and Capsules (50mg) is a semisynthetic podophyllotoxin derivative on the WHO Model List of Essential Medicines. It forms a ternary complex with DNA and topoisomerase II, preventing the re-ligation of cleaved DNA strands and causing permanent double-stranded breaks that arrest cells in late S and G2 phases. Indicated in combination chemotherapy for small cell lung cancer (SCLC), refractory testicular germ cell tumors, Hodgkin and non-Hodgkin lymphomas, and acute leukemias.
Etoposide Capsules 50 mg
Etoposide Injection (100mg/5ml) and Capsules (50mg) is a semisynthetic podophyllotoxin derivative on the WHO Model List of Essential Medicines. It forms a ternary complex with DNA and topoisomerase II, preventing the re-ligation of cleaved DNA strands and causing permanent double-stranded breaks that arrest cells in late S and G2 phases. Indicated in combination chemotherapy for small cell lung cancer (SCLC), refractory testicular germ cell tumors, Hodgkin and non-Hodgkin lymphomas, and acute leukemias.
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Etoposide.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Etoposide Injection 100 mg per 5 ml | Vial | ₹92.77 | PLACID, Posid, Etosid, Oncosid, Etoplast | ₹28.65 | N/A |
| Etoposide Capsules 50 mg | 8's | ₹202.50 | POSID | ₹389.69 | 48% Save |
Frequently Asked Questions (FAQ)
Get answers to common queries about Etoposide generics.