Dinoprostone

Active pharmaceutical substance formulated in Jan Aushadhi generic products for Women's Health & Hormones treatment.

🧴 Clinical Application

For endocervical administration ONLY by a qualified obstetrician in a hospital labor and delivery unit: Warm syringe to room temperature. Position patient in dorsal lithotomy, visualize cervix with speculum, insert the pre-filled catheter into cervical canal just below internal os, and slowly instill 0.5 mg (full syringe). The patient must remain recumbent in supine position for at least 30 minutes to minimize leakage. Continuous electronic fetal monitoring (CTG) and uterine activity monitoring required.

⚠️ Side Effects

Common: Mild uterine contractions, cervical soreness, nausea, vomiting, diarrhea, flushing, low-grade temperature elevation. Rare/Severe: Uterine hyperstimulation/tetanic contraction, uterine rupture, fetal distress/bradycardia, amniotic fluid embolism, and placental abruption.

🛡️ Safety Warnings

Contraindicated in patients with cephalopelvic disproportion, non-vertex presentation, fetal distress, unexplained vaginal bleeding during current pregnancy, placenta previa, multiparity (>=6 previous term pregnancies), previous cesarean section or major uterine surgery, and acute pelvic inflammatory disease. Wait at least 6 hours before initiating intravenous oxytocin.