Desmopressin

Active pharmaceutical substance formulated in Jan Aushadhi generic products for Kidney & Urinary Care treatment.

🧴 Clinical Application

Primary nocturnal enuresis: Take 0.1 mg to 0.2 mg orally at bedtime with a minimal sip of water. CRITICAL: Strictly restrict fluid intake from 1 hour before bedtime until 8 hours the following morning. Central diabetes insipidus: 0.1 mg three times daily with water, titrated based on urine volume and osmolality.

⚠️ Side Effects

Common: Headache, nausea, mild abdominal pain. Rare/Severe: Severe dilutional hyponatremia, water intoxication, cerebral edema, seizures, and coma if fluid restriction is ignored.

🛡️ Safety Warnings

Black Box Warning: Severe, potentially fatal hyponatremic seizures; fluid restriction is mandatory during nighttime enuresis therapy. Check baseline serum sodium and monitor periodically, especially in elderly patients. Contraindicated in polydipsia, hyponatremia, heart failure, and moderate-to-severe renal impairment (CrCl < 50 mL/min).