Cyclosporin
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Oncology & Critical Care treatment.
🧴 Clinical Application
Take orally in two divided doses every 12 hours on a consistent schedule with respect to meals with water. Swallow capsules whole. Therapeutic Drug Monitoring (TDM) is MANDATORY: regularly measure trough whole blood concentrations (C0) or 2-hour post-dose levels (C2) to titrate dosing within the narrow therapeutic window.
⚠️ Side Effects
Common: Dose-dependent nephrotoxicity, hypertension, hirsutism / hypertrichosis, gingival hyperplasia, tremor, headache, hyperkalemia, hypomagnesemia. Rare/Severe: Thrombotic microangiopathy / HUS, severe opportunistic infections, neurotoxicity (convulsions), and secondary lymphomas.
🛡️ Safety Warnings
Black Box Warning: Nephrotoxicity and hypertension; close monitoring of serum creatinine, blood pressure, and trough blood levels is essential. Black Box Warning: Increased susceptibility to severe opportunistic infections and lymphoma. Substrate of CYP3A4 and P-gp; grapefruit juice increases blood levels dramatically. Avoid live vaccines.
Jan Aushadhi Products containing Cyclosporin
Found 2 generic formulation(s) containing this active ingredient.
Cyclosporin capsules 50mg
Cyclosporine / Cyclosporin Capsules (25mg, 50mg, 100mg) is a cyclic polypeptide calcineurin inhibitor on the WHO Model List of Essential Medicines. Inside T-helper lymphocytes, it binds to the immunophilin cyclophilin; the resulting complex inhibits calcineurin phosphatase, preventing the dephosphorylation and nuclear translocation of nuclear factor of activated T-cells (NF-AT). This completely suppresses transcription of interleukin-2 (IL-2) and subsequent T-cell activation and proliferation. Indicated for prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants, and severe rheumatoid arthritis, psoriasis, and nephrotic syndrome.
Cyclosporin Capulses 25mg
Cyclosporine / Cyclosporin Capsules (25mg, 50mg, 100mg) is a cyclic polypeptide calcineurin inhibitor on the WHO Model List of Essential Medicines. Inside T-helper lymphocytes, it binds to the immunophilin cyclophilin; the resulting complex inhibits calcineurin phosphatase, preventing the dephosphorylation and nuclear translocation of nuclear factor of activated T-cells (NF-AT). This completely suppresses transcription of interleukin-2 (IL-2) and subsequent T-cell activation and proliferation. Indicated for prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants, and severe rheumatoid arthritis, psoriasis, and nephrotic syndrome.
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Cyclosporin.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Cyclosporin capsules 50mg | 5's | ₹120.00 | Panimun Bioral | ₹292.92 | 59% Save |
| Cyclosporin Capulses 25mg | 5's | ₹72.00 | Psorid, Iminoral | ₹138.28 | 48% Save |
Frequently Asked Questions (FAQ)
Get answers to common queries about Cyclosporin generics.