Clomiphene

Active pharmaceutical substance formulated in Jan Aushadhi generic products for Women's Health & Hormones treatment.

🧴 Clinical Application

Take orally 50 mg once daily with water for 5 consecutive days, starting on Day 2, 3, or 5 of the spontaneous or progestin-induced menstrual cycle. Ovulation typically occurs 5 to 10 days after the last tablet. If ovulation fails to occur, dose may be escalated in the subsequent cycle to 100 mg daily for 5 days under transvaginal ultrasound folliculometry. Maximum recommended treatment duration is 6 ovulatory cycles.

⚠️ Side Effects

Common: Vasomotor flushes (hot flashes), abdominal/pelvic bloating, breast tenderness, ovarian enlargement, nausea, headache, mood swings, and visual blurring (scotomas/spots). Rare/Severe: Ovarian Hyperstimulation Syndrome (OHSS), multiple gestation (twin pregnancy in ~8-10%), ovarian cyst torsion, and retinal vascular disturbances.

🛡️ Safety Warnings

Black Box Warning: Discontinue immediately if visual disturbances occur. Contraindicated in established pregnancy, uncontrolled thyroid or adrenal dysfunction, liver disease, abnormal uterine bleeding of undetermined origin, ovarian cysts not due to PCOS, and hormone-dependent neoplasms. Baseline pelvic ultrasound recommended.