Carboplatin
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Oncology & Critical Care treatment.
🧴 Clinical Application
Administer intravenously only over 15 to 60 minutes diluted in 5% Dextrose or 0.9% NaCl. Calculate dose using the Calvert formula based on patient's GFR. Cycles typically repeat every 4 weeks. Vigorous pre-hydration is not routinely required unlike cisplatin.
⚠️ Side Effects
Common: Dose-limiting myelosuppression (severe thrombocytopenia with nadir at days 21-28, neutropenia, anemia), nausea, vomiting, asthenia, alopecia. Rare/Severe: Hypersensitivity reactions (risk increases after 6+ cycles), secondary acute leukemia, and neurotoxicity.
🛡️ Safety Warnings
Black Box Warning: Bone marrow suppression is dose-limiting, especially thrombocytopenia; monitor CBC with platelet count weekly. Black Box Warning: Anaphylaxis/severe allergic reactions (erythema, bronchospasm, hypotension), particularly in patients previously exposed to platinum therapy. Adjust dose strictly according to renal function.
Jan Aushadhi Products containing Carboplatin
Found 2 generic formulation(s) containing this active ingredient.
Carboplatin Injection 150mg
Carboplatin Injection (150mg, 450mg) is a second-generation platinum antineoplastic agent on the WHO Model List of Essential Medicines. It incorporates a bidentate cyclobutanedicarboxylate leaving group that slows activation kinetics, producing DNA crosslinks similar to cisplatin but with dramatically reduced nephrotoxicity, ototoxicity, and emetogenicity. Dosing is individualized using the Calvert formula: Total Dose (mg) = Target AUC × (GFR + 25). Indicated for initial and palliative chemotherapy of advanced ovarian carcinoma, small cell lung cancer, non-small cell lung cancer, and head and neck neoplasms.
Carboplatin Injection 450mg
Carboplatin Injection (150mg, 450mg) is a second-generation platinum antineoplastic agent on the WHO Model List of Essential Medicines. It incorporates a bidentate cyclobutanedicarboxylate leaving group that slows activation kinetics, producing DNA crosslinks similar to cisplatin but with dramatically reduced nephrotoxicity, ototoxicity, and emetogenicity. Dosing is individualized using the Calvert formula: Total Dose (mg) = Target AUC × (GFR + 25). Indicated for initial and palliative chemotherapy of advanced ovarian carcinoma, small cell lung cancer, non-small cell lung cancer, and head and neck neoplasms.
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Carboplatin.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Carboplatin Injection 150mg | 15 ml Vial | ₹386.72 | CARBOPLATIN | ₹744.07 | 48% Save |
| Carboplatin Injection 450mg | 45 ml Vial | ₹1600.31 | CARBOKEM | ₹2099.20 | 24% Save |
Frequently Asked Questions (FAQ)
Get answers to common queries about Carboplatin generics.