Azathioprine
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Oncology & Critical Care treatment.
🧴 Clinical Application
Take orally 1 mg to 3 mg/kg daily as a single dose or two divided doses with or after meals with water to reduce gastric irritation. Prior to therapy, consider testing for Thiopurine S-methyltransferase (TPMT) and NUDT15 genotype or activity.
⚠️ Side Effects
Common: Dose-dependent bone marrow suppression (leukopenia, thrombocytopenia, anemia), nausea, vomiting, anorexia, hepatotoxicity (elevated transaminases/cholestasis). Rare/Severe: Fatal pancytopenia in TPMT/NUDT15 deficient patients, acute pancreatitis, severe infections, and secondary malignancies (lymphoma).
🛡️ Safety Warnings
Black Box Warning: Chronic immunosuppression increases risk of malignancy, particularly lymphomas and non-melanoma skin cancer. Black Box Warning: Severe bone marrow suppression; monitor complete blood counts weekly during initial months. MAJOR DRUG INTERACTION: Co-administration with allopurinol or febuxostat (xanthine oxidase inhibitors) blocks 6-MP degradation, causing lethal bone marrow aplasia; if combination is unavoidable, reduce azathioprine dose to 25-33% of standard dose.
Jan Aushadhi Products containing Azathioprine
Found 1 generic formulation(s) containing this active ingredient.
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Azathioprine.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Azathioprine Tablets 50 mg | 10's | ₹45.00 | AZORAN, AZR, AZAPURE, AZATHIOL, ATZ | ₹111.73 | 60% Save |
Frequently Asked Questions (FAQ)
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