Allopurinol

Active pharmaceutical substance formulated in Jan Aushadhi generic products for Pain, Fever & Arthritis treatment.

🧴 Clinical Application

Take orally 100 mg to 300 mg once daily immediately after meals with a full glass of water. Titrate upward every 2 to 4 weeks until serum uric acid drops below the target of <6.0 mg/dL (or <5.0 mg/dL in severe tophaceous gout). Maintain vigorous hydration (at least 2 to 3 liters of fluid daily). MANDATORY: Co-administer prophylactic colchicine (0.5 mg daily) or an NSAID during the first 3 to 6 months to prevent paradoxical gout flare-ups.

⚠️ Side Effects

Common: Maculopapular rash, diarrhea, nausea, asymptomatic transaminase elevations, initial gout flare-ups. Rare/Severe: Allopurinol Hypersensitivity Syndrome (AHS: life-threatening triad of rash/TEN, eosinophilia, systemic vasculitis, hepatitis, and acute renal failure), and Stevens-Johnson syndrome.

🛡️ Safety Warnings

Black Box Warning: Discontinue IMMEDIATELY at the earliest sign of skin rash, hives, or fever (rash may herald fatal Allopurinol Hypersensitivity Syndrome). Screening for the HLA-B*58:01 allele is strongly recommended in patients of Asian descent (very high risk of SJS/TEN). Do NOT initiate during an acute gout attack; wait until the acute flare has resolved. Reduce dose in renal impairment. MAJOR DRUG INTERACTION: Co-administration with azathioprine or 6-MP causes fatal bone marrow aplasia (reduce azathioprine dose by 75%).